Rapid Decrease in Peripheral Blood Mononucleated Cell Telomere Length After HIV Seroconversion, but Not HCV Seroconversion

Homeostasis of telomere length rather than telomere shortening after allogeneic peripheral blood stem cell transplantation.

Hematopoietic reconstitution after stem cell transplantation requires excessive replicative activity because of the limited number of stem cells that are used for transplantation. Telomere shortening has been detected in hematopoietic cells after bone marrow transplantation. This has been thought to result from excessive replication of the stem cells, with putative concomitant reduction of thei...

Absence of seroconversion in a PCR-positive person 18 months after transfusion of HIV-infected blood.

The donor, a 25-year-old man was a regular blood donor who has been tested for HIV 1 antibodies and found to be negative till September 1987. Three months later, in December 1987, this donor had seroconverted. Much later, we heard that homosexual contacts, dated July 1987, were most probably at the origin of the HIV 1 contamination. In December 1987, no antigen could be detected in his serum by...

Changes over time in post-seroconversion CD4 cell counts in the Italian HIV-Seroconversion Study: 1985-2002.

OBJECTIVE To determine whether there has been a tendency for early post-seroconversion CD4 cell counts to change over calendar time. DESIGN A prospective cohort study of individuals with well-estimated dates of seroconversion. METHODS We studied 1251 individuals who seroconverted to HIV in Italy between 1985 and 2002, and for whom the first CD4 count was measured within 2 years of seroconve...

Rape and subsequent seroconversion to HIV.

HIV Seroconversion in blood donors from the coordinating blood bank in the State of Pará

BACKGROUND Transfusion of Human immunodeficiency virus (HIV) infected blood is probably the most effective means of transmission of this disease. Despite intense efforts and investment to ensure safety, transmission of HIV still remains a real possibility in the transfusion service due to the fact that routine laboratory tests in most Brazilian government blood banks rely on the detection of an...